Endothelial cell inflammatory response to endotoxin needs actin polymerization.

2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Actin polymerization to produce stress fibers, ICAM-I and IL-8 expression are endothelial cell proinflammatory activities when challenged with endotoxin.

"Endotoxin-induced intercellular adhesion molecule-1 (ICAM-1) and IL-8 production in endothelial cells, which is mediated by Toll-receptor signaling, is essential for optimal neutrophil recruitment and migration during sepsis. Endotoxin also causes stress fiber polymerization that has recently been shown to affect intracellular signaling. However, the role of this polymerization process on endothelial-induced neutrophil adhesion and migration is unknown," investigators in the …